Identification of drug induced electrical instability of the heart curtails development, and introduction, of potentially proarrhythmic drugs.This problem usually requires complimentary contact based approaches such as patch-clamp electrophysiology combined with field stimulation electrodes to observe and control the cell.This produces data with hi

Poly(ADP-Ribose) polymerases (PARPs) are enzymes that metabolize NAD+.PARP1 and PARP10 were previously implicated in the regulation of autophagy.Here we showed that cytosolic electron-dense particles appear in the cytoplasm of C2C12 myoblasts in which PARP2 is silenced by shRNA.The cytosolic electron-dense bodies resemble autophagic vesicles and, i

Background: We established that the age at inception of T1DM significantly impacts the long-term risk of developing proliferative retinopathy in affected children and adolescents.Patients with T1DM, diagnosed before the age of 15 are at a significantly higher risk than children diagnosed at age 15 and older.For instance, several studies show change

Human being should be seen as the most important asset of economic life, and its well-being should be considered as an important indicator in having a realistic account regarding the level of prosperity and evolution of a nation.Although the concept of GNH (Gross Health Care National Happiness) has been introduced by economists like Richard Layard,